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    Basic and Applied Research
  • ● Basic and Applied Research
    Development of a motor function indicator system for frailty assessment in older adults and its preliminary application
    Liu Yujie, Liu Jingmin
    2025, 1(6): 1-8. https://doi.org/10.3969/j.issn.2097-5457.2025.10.002
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    Objective: This study aimed to establish an objective and quantitative assessment system for motor function in elderly frailty. The goal was to overcome the subjectivity and limitations of traditional evaluation methods, thereby providing a scientific basis for precise frailty screening and the development of efficient assessment systems. Methods: Motor function data from 2263 elderly individuals were standardized. Factor analysis was then employed to extract common factors and calculate hierarchical indicator weights. Results: An assessment system comprising movement function, body composition, and muscle strength was established. The comprehensive weights for each second-level and third-level indicator were clarified, and an evaluation standard was derived. Based on this system, an automated assessment system has been developed and implemented. Conclusion: The developed system provides a scientific and quantitative solution for frailty assessment. It features standardized testing, low cost, and short duration, making it suitable for both clinical evaluation and large-scale screening. This system holds significant application value in enhancing the early detection and intervention efficiency for elderly frailty.
  • ● Basic and Applied Research
    Research on screening potential key genes in tendinopathy based on bioinformatics analysis
    Guo Liwei, Li Haiwei, Liu Dan, Cheng Peipei, Luo Liang
    2025, 1(6): 9-20. https://doi.org/10.3969/j.issn.2097-5457.2025.06.002
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    Objective: The aim of this study was to identify the key genes in the diseased tendon tissues of patients with tendon disease by bioinformatics methods, and analyze their functions, in order to provide a new perspective for the pathogenesis and treatment of tendon disease. Methods: The human gene expression information set of GSE26051 was downloaded from the human gene expression database GEO. GO enrichment analysis was used to investigate the biological processes related to DEGs in tendon disease tissues. Perform pathway enrichment analysis on these DEGs using KEGG. Establish a PPI network through the interactive gene search tool STRING database. Use the MCODE plugin provided by CytoScape software to screen the core modules and key genes of the PPI network. Results: A total of 680 DEGs were identified between normal and diseased tendon tissues, of which 186 genes were up-regulated and 494 genes were down-regulated. These DEGs were mainly enriched in cytoskeleton, adhesion plaques, actin skeleton regulation and calcium signaling pathway. Finally, FN1, TTN and MYL2 were identified as key node genes through the machine algorithm in Cytoscape software. Conclusion: Based on the comprehensive bioinformatics analysis, the key genes in the development of tendinopathy were identified. As hub genes, FN1, TTN and MYL2 can be used as early biomarkers and molecular therapeutic targets for tendon injury, which can be used to guide drug and basic research, and provide scientific basis for exploring new therapeutic targets for tendon diseases.
    • Clinical and Training Practice
  • ● Clinical and Training Practice
    Clinical application of whole-body vibration training in the rehabilitation of basketball players with patellofemoral pain syndrome
    Tang Kun, He Sen, Gao Ruifang
    2025, 1(6): 21-25. https://doi.org/10.3969/j.issn.2097-5457.2025.12.001
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    Objective: To investigate the effects of whole-body vibration training on pain, function, and quality of life in basketball players with patellofemoral pain syndrome (PFPS). Methods: Thirty patients with PFPS were randomly divided into a control group and an experimental group, with 15 participants in each group. Control group underwent hip and knee muscle strength training, while experimental group received the same strength training combined with whole-body vibration training (frequency 50 Hz, amplitude 3 mm). The intervention lasted for 12 weeks, with three sessions per week. Assessments, including the Visual Analog Scale (VAS), Kujala score, Y-Balance test, SF-36 quality of life scale, and isokinetic muscle strength testing, were conducted before and after the intervention. Results: After the intervention, experimental group showed a significant reduction in VAS scores and a significant increase in Kujala scores compared to baseline (P< 0.05), with the improvements being significantly greater than those in control group (P< 0.05). SF-36 assessment revealed that experimental group had significantly higher scores in bodily pain and general health compared to control group (P< 0.05). Muscle strength testing indicated that experimental group demonstrated significantly enhanced knee flexion and extension strength, and a significantly lower 60°/s flexion/extension peak torque ratio compared to control group (P< 0.05). Conclusion: Whole-body vibration training combined with hip and knee muscle strengthening can effectively alleviate pain, improve knee function, enhance lower limb muscle strength, and promote quality of life in patients with PFPS.
  • ● Clinical and Training Practice
    The effect of acupuncture combined with the new Bobath therapy on gait stability and mobility in patients with post-stroke foot drop
    Niu Yi, Shi Zhuolin
    2025, 1(6): 26-30. https://doi.org/10.3969/j.issn.2097-5457.2025.10.006
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    Objective: To analyze the effect of acupuncture combined with the new Bobath therapy on gait stability and mobility in patients with post-stroke foot drop. Methods: 112 patients with post-stroke foot drop were randomly divided into two groups using the double-blind method. Both groups received basic treatment, with the control group (56 cases) receiving the new Bobath therapy and the observation group (56 cases) receiving acupuncture in combination. The clinical efficacy, improvement rate of toe flexion, lower limb muscle strength, and walking ability of the two groups were compared before and after treatment. Results: The clinical efficacy of the observation group was 98.21%, and the excellent rate of toe flexion improvement was 80.36%, both higher than the control group′s 87.50% and 60.72% (P<0.05). There was no statistically significant difference in the scores of Manual Muscle Test (MMT), Modified Ashworth Scale (MAS), Berg Balance Scale (BBS), 10 Maximum Walking Speed (10MWS), stride length, and stride width between the two groups before treatment (P>0.05). After treatment, the MMT score, BBS score, 10MWS, and stride length of both groups increased, and the observation group was higher than the control group (P<0.05). After treatment, the MAS scores and step widths of both groups decreased, and the observation group was lower than the control group (P<0.05). Conclusion: In the clinical treatment of post-stroke foot drop patients, acupuncture combined with the new Bobath therapy can effectively improve patients′ clinical symptoms, enhance their lower limb muscle strength, improve gait stability and mobility.
  • ● Clinical and Training Practice
    Meta-analysis of the differential effects of aerobic or combined nutritional resistance training on muscle strength and function in elderly patients with sarcopenia
    Wang Fei, Wang Hangping, Hao Ziwei, Gong Lingxuan, Dai Rongjuan
    2025, 1(6): 31-46. https://doi.org/10.3969/j.issn.2097-5457.2025.12.002
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    Objective: To systematically analyze the effects of resistance exercise combined with aerobic exercise and resistance exercise combined with enhanced nutrition on physical function in elderly patients with sarcopenia. Methods: Randomized controlled trials on the intervention of resistance exercise combined with nutritional supplements or aerobic exercise for elderly patients with sarcopenia were retrieved through CNKI, VIP database, Wanfang database, Web of Science, Elsevier ScienceDirect full-text database and PubMed database, and Meta analysis was performed using RevMan5.3 software. Results: In interventions targeting grip strength in elderly patients with sarcopenia, the mean effect size [MD = 2.60, 95% CI (2.38, 2.82), P<0.00001] of resistance exercise combined with enhanced nutrition was significantly greater than that of resistance exercise combined with aerobic exercise [MD = 1.39, 95% CI (0.92, 1.85), P < 0.00001]. Regarding walking speed metrics, the mean standardized effect size [SMD = 0.80, 95% CI (0.60, 1.01), P < 0.00001] of resistance exercise combined with aerobic exercise exceeded that of resistance exercise combined with enhanced nutrition [SMD = 0.64, 95% CI (0.42, 0.86), P<0.00001]. For the four-limb skeletal muscle mass index, the mean effect size [MD = 0.31, 95% CI (0.19, 0.43), P < 0.00001] of resistance exercise combined with aerobic exercise surpassed that of resistance exercise combined with enhanced nutrition [MD = 0.11, 95% CI (0.01, 0.22), P = 0.04]. In short physical performance battery, the mean effect size [MD = 1.93, 95% CI (1.57, 2.29), P<0.00001] of resistance exercise combined with enhanced nutrition was significantly larger than that of resistance exercise combined with aerobic exercise [MD = 0.86, 95% CI (0.64, 1.07), P < 0.00001]. Conclusion: Resistance training combined with enhanced nutrition and aerobic exercise shows significant improvement effects on physical function in elderly patients with sarcopenia. However, the effect sizes of these two approaches vary across different diagnostic indicators, with distinct age-related and cycle-specific emphases. In practical implementation, intervention methods should be tailored to patients′ actual conditions, time availability, needs, and preferences to provide high-quality preventive interventions.
  • ● Clinical and Training Practice
    A study on the efficacy of Schroth exercise therapy for adolescent idiopathic scoliosis in female children aged 8~12 years
    Yu Yafei, Song Wei, Wang Jialei, Xing Xiaotian, Yun Xinghao
    2025, 1(6): 47-52. https://doi.org/10.3969/j.issn.2097-5457.2025.11.001
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    Objective: To investigate the therapeutic effect of an 8-week intervention using Schroth exercise therapy on mild adolescent idiopathic scoliosis (AIS) in female children aged 8~12 years. Methods: Thirty-seven female children (aged 8~12 years) with mild scoliosis, were selected and randomly assigned to either an experimental group (n=19) or a control group (n=18). The experimental group received targeted rehabilitation training using the Schroth exercise therapy, while the control group received routine health education and daily postural guidance. The Cobb angle, Angle of Trunk Rotation (ATR), Scoliosis Research Society22 (SRS-22) questionnaire score, and Risser Vertebral Axis Deviation (RVAD) were compared between the two groups before treatment and after 8 weeks of treatment. Results: Before treatment, there were no statistically significant differences in the Cobb angle, ATR, SRS-22 score, or RVAD between the two groups (P>0.05). After 8 weeks of treatment, the experimental group showed significantly lower values than the control group in the Cobb angle (8.21±1.53° vs. 12.35±1.86°), ATR (3.12±0.87°vs. 5.89±1.03°), and RVAD (5.34±1.21° vs. 8.76±1.54°). Conversely, the SRS-22 score was significantly higher in the experimental group (4.23±0.35) compared to the control group (3.56±0.42). All these post-treatment differences were statistically significant (P< 0.05). Conclusion: Schroth exercise therapy can effectively improve the degree of curvature, trunk rotation, and quality of life in female children aged 8~12 years with mild scoliosis within 8 weeks, demonstrating significant short-term efficacy. It is worthy of clinical promotion and application.
  • ● Clinical and Training Practice
    Association study between mercury migration and transformation of coal and osteoporosis based on the NHANES database
    Li Chenyu, Huang jie
    2025, 1(6): 53-61. https://doi.org/10.3969/j.issn.2097-5457.2025.08.002
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    Objective: To investigate the potential association between mercury, a harmful component in coal, and the risk of osteoporosis, thereby providing evidence for osteoporosis prevention and environmental management strategies. Methods: A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES, 2017-2020). Between-group differences were evaluated using t-test, non-parametric tests, or chi-square tests as appropriate. Blood mercury levels were categorized by quartiles, and their association with osteoporosis was assessed through multivariable logistic regression models. The dose-response relationship was examined using restricted cubic spline analysis and threshold effect analysis, complemented by stratified subgroup analyses. Results: Among 1870 participants, the prevalence of osteoporosis was 72.89%. Individuals with osteoporosis exhibited higher blood mercury levels (1.64±2.52μg/L) compared to those without osteoporosis (1.37±2.29μg/L). After adjusting for all potential confounders, multivariable logistic regression analysis revealed that blood mercury remained an independent risk factor for osteoporosis, with the highest quartile (Q4) demonstrating significantly elevated risk compared to the lowest quartile (Q1) [OR=1.55, 95% CI(1.10, 2.17), P=0.011]. Restricted cubic spline analysis indicated a non-linear relationship between blood mercury levels and osteoporosis risk (non-linearity P=0.005). Conclusion: Elevated blood mercury levels are significantly associated with increased risk of osteoporosis, suggesting that reducing exposure to mercury from coal-derived sources may serve as a potential preventive strategy against osteoporosis development.
  • ● Clinical and Training Practice
    Clinical efficacy of warm moxibustion combined with scraping therapy and Baduanjin in the treatment of axial neck pain
    Bu Haihua, Sun Jing, Ye Kun, Zhao Jing
    2025, 1(6): 62-67. https://doi.org/10.3969/j.issn.2097-5457.2025.09.002
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    Objective: To observe the clinical efficacy of warm moxibustion combined with scraping therapy and Baduanjin in the treatment of axial neck pain. Methods: 76 patients with axial neck pain admitted from January to December 2024 were randomly divided into two groups using a random number table method. The control group (38 cases) received ultra short wave treatment and health education, while the observation group (38 cases) received warm moxibustion and scraping therapy combined with Baduanjin treatment, with 1~2 times a week as one course of treatment for 4 consecutive weeks. Observe the changes in Visual Analogue Scale (VAS), Neck Pain Scale (NPQ), Neck Dysfunction Index (NDI), and Yasuhisa Tanaka Symptom Scale scores of the two groups of patients before and after treatment, as well as the pain relief rate. Results: The gender, age, disease duration, VAS score, NPQ score, NDI score, and Tanaka Yasuhisa Symptom Scale score of the two groups of patients before treatment were comparable. After treatment, the VAS scores, NPQ scores, and NDI scores of both groups were lower than those before treatment, and the scores of the Yasuhisa Tanaka Symptom Scale were higher than those before treatment. The differences were statistically significant (P<0.001), and the VAS scores, NPQ scores, and NDI scores of the observation group were all lower than those of the control group. The score of the Symptom scale of Yasuhisa Tanaka was higher than that of the control group, and the difference was statistically significant (P<0.05). The pain relief rate of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: Warm moxibustion therapy combined with scraping and Badunjin can relieve axial neck pain, improve the range of motion and cervical spine function, enhance patients′ quality of life. This combined therapy deserves widespread promotion.
    • Review
  • ● Review
    Research progress of artificial intelligence in postoperative rehabilitation of anterior cruciate ligament reconstruction surgery
    Li Bingjie, Yan Shan, Zhao Lei, Liu Ruiting, Xu Tuanjie, Li Yuanyuan, Xie Suli
    2025, 1(6): 68-73. https://doi.org/10.3969/j.issn.2097-5457.2025.10.003
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    As a crucial approach to restoring knee joint stability and reducing secondary injuries, Anterior Cruciate Ligament Reconstruction (ACLR) directly determines the degree of patients′ joint function recovery and quality of life through its postoperative rehabilitation outcomes. Although the accumulation of evidence-based evidence and clinical promotion of Artificial Intelligence (AI) in the field of ACLR postoperative rehabilitation are still in their infancy, AI has demonstrated enormous potential to break through the limitations of traditional rehabilitation. This study aims to systematically review the research status of AI in ACLR postoperative rehabilitation in recent years, conduct an in-depth analysis of the differences in adaptability of different AI technologies in aspects such as functional monitoring, training guidance, and risk prevention and control, and clarify the existing technical bottlenecks and clinical pain points in the current field by comparing the research progress at home and abroad.
  • ● Review
    The effect of progressive resistance training on limb function rehabilitation following stroke
    Wang Qi, Wang Zhaowei, Liu Rui
    2025, 1(6): 74-81. https://doi.org/10.3969/j.issn.2097-5457.2025.10.004
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    Objective: The aim of this study is to summarize the latest research progress of progressive resistance training in the field of limb function rehabilitation after stroke, with a view to providing a theoretical basis for clinical practice and pointing out the direction for subsequent research. Methods: The literature review method was used to systematically sort out the relevant literature on progressive resistance training in post-stroke physical rehabilitation at home and abroad, focusing on analyzing the effects of exercise intervention, the mechanism of action, and the results of the study. Results: Progressive resistance training has a significant effect on the recovery of limb function after stroke. This training method can effectively enhance muscle strength, promote neuroplasticity, improve walking ability, balance function and daily life ability, which provides important support for the rehabilitation of stroke patients. Progressive resistance training should be considered as a key component in stroke rehabilitation. Conclusion: Exercise is a key factor in the recovery of limb function after stroke, and progressive resistance training, as a biomechanical therapy, has a significant impact in improving the strength of stroke patients.
  • ● Review
    Research progress on the mechanism of chronic ankle instability
    Ling Zesha, Wang Lan, Lei Yalin, Bai Xingang, Que Fangxu, Tang Zhaobing, Zheng Jinqi, Dong Chao, Pang Rizhao
    2025, 1(6): 82-85. https://doi.org/10.3969/j.issn.2097-5457.2025.10.005
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    Research of chronic ankle instability has progressed beyond the traditional view focused solely on structural ligamentous damage (mechanical instability) to incorporate a dual-dimensional model encompassing neurosensory-motor integration dysfunction (functional instability). This understanding has further evolved into a syndrome framework involving multifactorial interactions. This article systematically reviews the latest research progress on the pathological mechanisms of CAI, aiming to provide a theoretical basis for optimizing clinical management and rehabilitation strategies, and to outline key directions for future research.
  • ● Review
    Design and application of multi-agent-driven personalized exercise systems
    Guo Lei, Zhao Jianing, Yuan Xiaowei
    2025, 1(6): 86-94. https://doi.org/10.3969/j.issn.2097-5457.2025.08.007
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    Regular exercise is especially important for keeping people healthy and preventing chronic diseases. Scientific assessment and targeted preventive measures can effectively reduce exercise risks. Previous methods of preventing sports injuries and helping to recover are mainly based on the doctor′s own experience and some fixed rules. Although these old methods are useful to most people, they cannot be adjusted according to each person′s different circumstances and environmental variables. In view of this, a personalized exercise system driven by multi-agent coordinates globally through a central coordinating agent, deeply integrating the semantic parsing and reasoning capabilities of large language models, multimodal data perception, and professional analysis tools to achieve dynamic task decomposition, real-time tool invocation, and closed-loop feedback optimization. This system presents universal value in personalized training guidance, injury risk warning, and rehabilitation management. With data-driven dynamic decision-making replacing empirical intervention, it provides an innovative technological path for reducing exercise-related risks and improving access to health services.