Clinical and Training Practice
Zhao Xin, Wang Zhijiang Guo, Pengcheng, Liang Xinwen
Objective: To systematically evaluate the global efficacy of exercise on body composition, body functions, inflammation, and metabolic indicators in older patients with sarcopenic obesity and to generate an evidence-based rationale for its promotion and application. Methods: Databases including CNKI, WanFang, VIP, PubMed, Web of Science, Embase, and Scopus were extensively reviewed from inception to January 2024. Literature assessment, data extraction, and quality assessment were conducted by two independent researchers using Cochrane Evaluation Tool, Review Manager 5.4 for meta-analysis, and funnel plot testing for publication bias. Results: A total of 11 studies involving 664 patients were selected. Exercise can markedly lessen patient body mass index (P<0.001), body fat rate (P<0.001), and visceral fat area (P<0.001), yet it does not enhance total skeletal muscle mass (P=0.86), nor skeletal muscle mass index (P=0.28). Exercise can notably improve patient grip strength (P=0.02), gait speed (P=0.01), chair up test (P<0.001) and single leg standing time (P=0.10), while minimizing stand walk timing test duration (P<0.001). Exercise noticeably elevates IGF-1 levels in patients (P=0.002), while having minimal influence on IL-6 (P=0.62), C-reactive protein (P=0.20), leptin (P=0.29), Triglycerides (P=0.35) and total serum cholesterol (P=0.27). Conclusion: Exercise effectively reduces body fat, enhances physical function, and IGF-1 levels, while having no significant effect on muscle mass, inflammatory factors, and blood lipids.